Abstract
Intracerebral injection of angiotensin II induced drinking behavior in satiated rats. In the present experiments five rats, presenting a positve drinking response to the intraseptal injection of angiotensin II, were trained to press a lever for water in a standard chamber, used for operant behavior studies. The injection of 1 μg of angiotensin II into the septal area of the brain caused the animals, previously satiated in the experimental chamber, to resume lever pressing under a continuos reinforcement schedule of water presentation. The number of responses emitted after angiotensin was considerably higher than after a control injection of saline. This result supports the hypothesis that angiotensin has a dipsogenic action in the CNS that mimicks the effect of water deprivation.
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