Abstract
The aim of this study was to quantify soluble Fas/APO-1 (sFas/APO-1) protein in the serum of patients with Behcet's disease (BD) in active and inactive stages, compared with patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Soluble Fas/APO-1 was quantified using a sandwich enzyme-linked immunosorbent assay. Increased serum sFas/APO-1 levels were observed in active BD, compared with inactive BD, RA patients and SLE patients. Increased serum sFas/APO-1 levels were correlated with the presence of neurologic manifestations or pulmonary involvement in active BD. In conclusion, increased levels of sFas/APO-1 occurred frequently and exclusively in active BD patients. Preliminary evidence suggested that elevated levels of sFas/APO-1 are associated with the clinical stage and clinical manifestations in BD.
Highlights
Apoptosis or programmed cell death is an important mechanism that maintains cellular homeostasis.[1,2] The programmed cell death involves the interaction between surface and soluble molecules: bcl-2, Fas and Fas ligand.[3]
Fas/APO-1 receptor molecule w hich lacked the transmembrane segment, resulted in a soluble form of Fas/Apo-1.6. These studies suggested that elevated serum levels of sFas/Apo-1 receptor might provide a mechanism for downregulating programmed cell death, which could be important in the pathogenesis of several diseases: autoimmune and viral diseases
The ELISA values were expressed as mean ± SD, in 20 Behçet’s disease (BD) patients in inactive stage, in 30 active BD patients, in 23 systemic lupus erythematosus (SLE) patients and in 20 rheumatoid arthritis (RA) patients (Fig. 1)
Summary
Apoptosis or programmed cell death is an important mechanism that maintains cellular homeostasis.[1,2] The programmed cell death involves the interaction between surface and soluble molecules: bcl-2, Fas and Fas ligand.[3]. These studies suggested that elevated serum levels of sFas/Apo-1 receptor might provide a mechanism for downregulating programmed cell death, which could be important in the pathogenesis of several diseases: autoimmune and viral diseases
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