Levels of Serum sST2, MMP-3, and Gal-3 in Patients with Essential Hypertension and Their Correlation with Left Ventricular Hypertrophy.

Xueling Wang,Yun Fan,Wei Han,Lin Han,Kehui Li,Jiyuan Yang

doi:10.1155/2021/7262776

Abstract

Essential hypertension (EH) is a clinically frequent cardiovascular disease, with insidious onset, causing increased pressure load and neuroregulation disorders in patients. Long-term EH can cause left ventricular hypertrophy (LVH), which can lead to arrhythmia and even death. The soluble suppression of tumorigenicity 2 (sST2), matrix metalloproteinase-3 (MMP-3), and galectin-3 (Gal-3) in serum plays an important role in the occurrence, development, and prognosis of cardiovascular diseases. In our study, we divided EH patients into 3 levels and groups with or without LVH, according to their condition. The levels of sST2, MMP-3, and Gal-3 in the serum were measured in different groups of patients. Our results showed that the levels of sST2, MMP-3, and Gal-3 in the serum increased progressively with the level in different EH groups. The levels of sST2, MMP-3, and Gal-3 in the serum of the LVH group were higher than those of the NLVH group, and it is positively correlated with LVH-related indexes. The risk of developing and progressing to LVH in patients with EH can be determined by the method of measuring three indicators.

Highlights

Essential hypertension (EH) is a clinically frequent cardiovascular disease, with insidious onset, causing increased pressure load and neuroregulation disorders in patients
Long-term EH can cause left ventricular hypertrophy (LVH), which can lead to arrhythmia and even death. e soluble suppression of tumorigenicity 2, matrix metalloproteinase-3 (MMP-3), and galectin-3 (Gal-3) in serum plays an important role in the occurrence, development, and prognosis of cardiovascular diseases
Our results showed that the levels of suppression of tumorigenicity 2 (sST2), MMP-3, and Gal-3 in the serum increased progressively with the level in different EH groups. e levels of sST2, MMP-3, and Gal-3 in the serum of the LVH group were higher than those of the NLVH group, and it is positively correlated with LVH-related indexes. e risk of developing and progressing to LVH in patients with EH can be determined by the method of measuring three indicators

Summary

Introduction

Essential hypertension (EH) is a clinically frequent cardiovascular disease, with insidious onset, causing increased pressure load and neuroregulation disorders in patients. E soluble suppression of tumorigenicity 2 (sST2), matrix metalloproteinase-3 (MMP-3), and galectin-3 (Gal-3) in serum plays an important role in the occurrence, development, and prognosis of cardiovascular diseases. E levels of sST2, MMP-3, and Gal-3 in the serum were measured in different groups of patients. Our results showed that the levels of sST2, MMP-3, and Gal-3 in the serum increased progressively with the level in different EH groups. 1. Introduction e essential hypertension (EH) is a clinically frequent cardiovascular disease with insidious onset and protracted course. E EH patients are prone to left ventricular hypertrophy (LVH) due to increased pressure load and neuromodulation disorders, which seriously harms the prognosis of patients [4]. MMP-3 was positively correlated with cardiovascular and cerebrovascular events in patients with CAS, which could be used as a marker for the clinical diagnosis and prognosis assessment of patients with CAS

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Discussion

Conclusion