Levels of pro-inflammatory cytokines and markers of oxidative stress in mixed saliva of Bukhara oil refinery workers

Abstract

The study evaluated the biochemical effects of chronic exposure to the oil refining industry on the levels of pro-inflammatory cytokines and lipid peroxidation processes in the saliva of hazardous production workers. The workers of the main specialties of the Bukhara oil refinery were examined. The levels of pro-inflammatory cytokines both in the workers of the hazardous shops of the oil refinery and in the employees of the plant management were determined by the amount of destruction of the epithelial attachment of the gums, determined by the value of the CPI index. At the same time, with an increase in the severity of periodontal lesions, the concentrations of pro-inflammatory mediators significantly increased (P ≤ 0.05). in those examined with healthy periodontium (CPΙ -0), the concentration of TNF-α in the mixed saliva of workers in hazardous production exceeds that of employees of the plant management by 83.85% (P ≤ 0.01); in those examined with low values of the СPΙ index (1–2), this excess was 41.23% (P ≤ 0.01) and in severe lesions (СP Ι – 3–4) – 72.23% (P ≤ 0.01). In general, the concentration of TNF-α in the mixed saliva of workers at the enterprise exceeded that of employees of the plant management by 61.20% (P ≤ 0.01); the corresponding excess levels of IL-6 were 85.00%; 80.00%; 72.33% and 65.91% Thus, the production hazards of the oil refinery are a systemic risk factor for the development of periodontitis.