Levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in human milk from different regions of France

Abstract

We report on the pilot study carried out before the start of the Elfe project (French longitudinal study from childhood). A total of 44 samples of mature human milk were collected at home 8weeks after delivery. A total of 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs), 12 dioxin-like (DL) polychlorinated biphenyls (PCBs), and 6 non dioxin-like (NDL)-PCBs were measured. For total TEQ (PCDD/Fs and DL-PCBs), the geometric mean concentration was 17.81pg TEQWHO05/g lipids. Relative PCDD, PCDF, and DL-PCB contributions to the arithmetic mean TEQWHO05 were 38%, 18%, and 44%, respectively. The use of TEFWHO05 instead of TEFWHO98 resulted in a 27% reduction of the total TEQ value. Although PCDD levels did not significantly change (less than 0.5% increase), PCDF and DL-PCB levels both decreased by 35% and 38%, respectively. Levels have been compared to data obtained during a previous non-reported national study conducted in 1998 (TEFWHO98) in French lactaria (n=244). The mean of PCDD/Fs has decreased about 39.4% (18.8pg TEQWHO98/g lipids in 1998 vs 11.4pg TEQWHO98/g lipids in pilot study), respectively 41.5% for PCDDs (10.6pg TEQWHO98/g lipids in 1998 vs 6.2pg TEQWHO98/g lipids in pilot study) and 36.7% for PCDFs (7.9pg TEQWHO98/g lipids in 1998 vs 5.0pg TEQWHO98/g lipids in pilot study). For the sum of the 6 NDL-PCBs, the 2007 geometric mean concentration in milk was 176.3ng/g lipids. The arithmetic mean lipid concentration in 2007 breast milk was 26.4g/l (range from 6.0 to 46.7g/l). A PCDD/F and DL-PCB daily intake was estimated to be 62.3pg TEQWHO05/kg body weight per day (85.0pg TEQWHO98/kg body weight per day) for a baby of 5kg of body weight fed daily with 700ml of maternal milk containing 25g/l of lipids.