Abstract
Objective:To investigate the effects of levels of D-dimer and N-terminal pro-brain natriuretic peptide (NT-pro BNP) on the prognosis of patients with acute cerebral infarction.Methods:One hundred and twenty-four patients with acute cerebral infarction who were admitted to the hospital between July 2014 and July 2016 were selected as the observation group; 100 normal people who had health examination in the center of physical examination of our hospital were selected as the control group. The levels of D-dimer and NT-pro BNP of the two groups were observed; the correlation between the levels of plasma NT-pro BNP and D-dimer and area of cerebral infarction, complications and death condition of the observation group was investigated.Results:The levels of D-dimer and NT-pro BNP of the observation group were much higher than those of the control group, and the difference was statistically significant (P<0.05). The levels of D-dimer and NT-pro BNP of the observation group were significantly higher than those of the control group, and the difference had statistical significance (P<0.05). The levels of plasma NT-pro BNP and D-dimer of the patients with disturbance of consciousness and high blood pressure were apparently higher than those with no disturbance of consciousness and normal blood pressure, and there was a statistically significant difference (P<0.05). The patients were followed up for half a year. The levels of D-dimer and NT-pro BNP of the dead patients were much higher than those of the survived patients on admission.Conclusion:The levels of plasma NT-pro BNP and D-dimer can reflect the disease condition and prognosis of patients with acute cerebral infarction. Higher levels of NT-pro BNP and D-dimer indicates poorer prognosis. This work can provide a guidance for the clinical treatment of acute cerebral infarction.
Highlights
Cerebral infarction, a common cerebrovascular disease in clinic, is induced by local ischemia and necrosis of cerebral tissues
Inclusive criteria: Patients who had acute cerebral infarction that was diagnosed according to the Essentials of Diagnosis of Cerebrovascular Diseases which were approved by the Fourth Academic Conference of Cerebrovascular Diseases (1995) and based on the results of head Computed Tomography (CT) or Magnetic Resonance Inspection (MRI) and were admitted to the hospital within 24 hour after attack were included.[7]
Though the mechanism of increase of the level of NT-pro Brain Natriuretic Peptide (BNP) has not been thoroughly clarified, some scholars thought it might be contributed to local ischemia and hypoxia of cerebral tissues, abnormal secretion of nerve transmitters induced by strong stimulation on hypothalamo-hypophyseal system or tension of blood vessel wall induced by hemodynamic changes.[14,15]
Summary
A common cerebrovascular disease in clinic, is induced by local ischemia and necrosis of cerebral tissues. It is featured by sudden attack, high incidence of complications, high disability rate, high death rate and poor prognosis.[1,2] With the changes of living habits in recent years, the incidence of cerebral infarction shows a tendency of obvious increase.[3] Some patients with cerebral infarction have poor recovery after treatment. More effective diagnostic indicators are needed to provide an important significance for clinical treatment. Pak J Med Sci July - August 2018 Vol 34 No 4 www.pjms.com.pk 855
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