Abstract
The adjustment of the minimum inhibitory concentrations for anti-tuberculosis drugs used in classical cultivation methods and the obtaining of more accurate data on the level of drug resistance, makes it possible to evaluate cases with different results to phenotypic and genotypic methods of anti-tuberculosis resistance testing. The evaluation of different types of genotypic resistance, with the description of mutations that confer low or high resistance, is consistent with the level of phenotypic resistance, and also makes it possible to adjust treatment regimens, which ultimately will positively influence the duration and results of treatment. Whenever testing of M. tuberculosis resistance by molecular methods allows, the results should be reported with the specific mutations detected and the description of the clinical implications of this mutation.
Highlights
Levels of phenotypic resistance and the pattern of gene mutations of M. tuberculosis The adjustment of the minimum inhibitory concentrations for anti-tuberculosis drugs used in classical cultivation methods and the obtaining of more accurate data on the level of drug resistance, makes it possible to evaluate cases with different results to phenotypic and genotypic methods of anti-tuberculosis resistance testing
Whenever testing of M. tuberculosis resistance by molecular methods allows, the results should be reported with the specific mutations detected and the description of the clinical implications of this mutation
Testarea rezistenței M.tuberculosis la concentrații mai mari pentru RIF, ar putea fi considerată ca o opțiune pentru o combinație terapeutică în tratamentul pacienților cu TB MDR la care preparatele de linia 2 prezintă rezistență
Summary
De asemenea au fost evaluate discrepanțele prezente în rezultatele metodei culturale (MGIT 960) și molecular genetice – GeneXpert, GenoType MTBDRplus, MTBDRsl. Astfel, la evaluarea a 1327 de rezultate paralele obținute prin metoda culturală convențională BACTEC MGIT 960 și metoda molecular genetică GeneXpert MTB/RIF, GeneXpert MTB/Ultra sau înregis- La evaluarea a 1679 de rezultate paralele obținute prin metoda MGIT 960 și MTBDRplus sau înregistrat 1,3% discrepanțe la rezultatele sensibile pentru RIF (12 din 941 tulpini sensibile) și 1,1% la rezultatele rezistente pentru Rifampicină (8 din 738 tulpini rezistente).
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