Levels of paraoxonase, high-density lipoprotein and total sialic acid levels in patients with polycystic ovary syndrome

Abstract

Paraoxonase (PON1) have been considered to have a role in various pathological processes, including inflammatory response, cardiovascular disease and recently also in ovarian dysfunction. We aimed to evaluate relation high density lipoprotein cholesterol (HDL) levels and PON1 activity and total sialic acid status (TSA) levels in serum of patients with polycystic ovary syndrome (PCOS) and healthy individuals. Twenty PCOS patients (PCOS group) and 20 healthy nonhyperandrogenic women (control group) were studied in the current study. Levels of HDL, TSA, and activity of PON1 were measured in serum of PCOS patients. Levels of PON1 activity and level of HDL were significantly lower in the PCOS group than in the control group. TSA levels were higher in the PCOS group than the control group. There was also a significant correlation between the parameters and syndrome initiation. In conclusion, patients with PCOS had high level of PON1. It might be hypothesized that elevated serum TSA, HDL and PON1 may be associated with increased cardiovascular risk in PCOS and/or menstrual irregularities associated with this syndrome.