Abstract
The knowledge about the state of viral replication over the course of infection with the Human Immunodeficiency Virus type 1 (HIV-1) is still incomplete in spite of its important implications for the pathogenesis and transmission of AIDS. Silent HIV-1 infections might take place after the initial encounter with the virus; infected persons may remain seronegative for prolonged periods, suggesting that in this state very little, if any, viral RNA or protein is made and infectious virus is not released. In anti-HIV seropositive yet healthy individuals (“healthy carriers”), earlier studies using viral isolation techniques from peripheral blood mononuclear cells (PBMC) have also contributed to the notion that the number of infected cells in this subjects is low (at most 1 in 100 in 1 case only). Present reports on the presence of free virus in plasma or on antigen expression in sera or in cells are still scarce and controversial.
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