LEVELS OF ENZYMATIC ANTIOXIDANT SUPEROXIDE DISMUTASE AND NONENZYMATIC ANTIOXIDANT URIC ACID IN POLYCYSTIC OVARY SYNDROME PATIENTS IN A TERTIARY CARE HOSPITAL OF ASSAM

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders, occurring in 5–10% women in reproductive ages. Despite a long history of studies on PCOS, its aetiology is still unknown. Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including PCOS. Although intracellular reactive oxygen species (ROS) production and propagation are controlled by highly complex antioxidant enzymatic and non-enzymatic systems, understanding of mechanisms that oxidative stress is important to develop strategies for prevention and treatment of PCOS. Objectives: To estimate the serum levels of superoxide dismutase and uric acid in PCOS patients. Methodology:Acase-control study was conducted in a tertiary care hospital of Assam, with 60 PCOS patients attending the outpatient Department of Obstetrics and Gynaecology, Gauhati Medical College and Hospital (GMCH), Guwahati, Assam along with 60 healthy controls of same age group. The samples were evaluated by ELISA and VITROS 5600 Autoanalyser using standard kits and reagents in the Department of Biochemistry, GMCH. Results: The results were statistically analysed and the mean and SD of SOD were found to be 969.95 + 62.96 among the cases and 1298.8 + 137.8 among the controls with p value <0.001, whereas the mean and SD of uric acid was 5.41 + 0.70 in cases and 3.76 + 0.74 in controls with p value <0.001.Conclusions: Signicantly lower serum levels of SOD and signicantly higher levels of Uric acid were found in cases with PCOS compared to the control group.