Abstract
Chlorpromazine (CPZ), demethylated(nor1)-CPZ, 7-hydroxy(7-OH)-CPZ, and CPZ-nitrogenoxide-(NO) were administered to rats. Levels of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MOPEG) in the brain and prolactin in serum were determined. The HVA increase calculated per nmole unchanged drug in brain was about the same in the CPZ and 7-OH-CPZ groups, but nor1-CPZ was less than 50% as effective in this respect. When CPZ-NO was administered, high amounts of CPZ and nor1-CPZ were formed. The amounts of these products could fully explain the HVA elevation induced by CPZ-NO. The HVA levels were significantly correlated to the amount of the respective drug in the brain. After CPZ and 7-OH-CPZ the levels of unchanged drug in serum were about 3% of the brain level, while the drug serum/brain ratio was significantly lower in the nor1-CPZ-treated group. The prolactin level in serum was raised to about 200% of control 90 min after all drugs were administered. This may be explained by assuming a supramaximal stimulation of the prolactin release mechanism already being achieved at low drug levels in the brain. At 7.5 mg/kg none of the drugs affected the levels of MOPEG or 5-HIAA. After high doses of CPZ the level of MOPEG in the brain was increased.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
