Abstract
Objective: The mechanism(s) of increased sperm chromatin abnormalities/DNA damage in infertile men has not been established. However, such a defect has been recently attributed to abnormal apoptotic degeneration. The most characteristic feature of apoptosis is DNA double-strand breaks via activation of endogenous nucleases. In this study, we examined the susceptibility of sperm chromatin/DNA to acid-induced denaturation in situ, as assessed by the SCSA, in relation to levels of apoptosis in ejaculated spermatozoa.
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