Abstract

Neutrophils of the neonatal rat show decreased migration into the lung after hyperoxia compared to adults. To investigate the mechanism of this impairment, expression of the neutrophil adherence molecules, L-selectin and CD18, were examined on neonatal rat neutrophils at 0-24 hrs, 72 hrs, and 7, 10, 14, and 21 days of age. Staining of whole blood was analyzed by flow cytometry (results expressed as mean channel fluorescence). Soluble L-selectin in the serum was measured using a sandwich ELISA (results expressed as absorbance). Results are as follows (mean ± S.D., * p<0.05 for adult vs. neonate): Table

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