Levels of a select group of trace elements in scalp hair of schizophrenics by PIXE

Abstract

The levels of ten trace elements in the range Ca to As in the scalp hair of schizophrenics were analyzed using Particle Induced X-ray emission (PIXE) technique. Thirty males and females with a confirmed diagnosis of schizophrenia and an equal number of age-matched controls of both genders were chosen. The samples were excited with a proton beam of 2.5 MeV and spectra were scanned by a Si (Li) detector. The findings revealed a statistically significant difference in the concentration of six trace elements (Ca, Zn, Se, Mn, Fe, Ni, and Cu) in scalp hair of schizophrenia patients compared to controls, implying a disruption in the homeostasis of these elements. A plausible correlation of this imbalance with the etiology and pathology of schizophrenia is discussed.