Levels and clinical significance of serum SP-D and MBL in infants with cytomegalovirus pneumonia

Abstract

Objective To investigate the levels of serum surfactant protein D (SP-D) and mannose-binding lectin (MBL) in infants with cytomegalovirus (CMV) pneumonia with the severity of disease. Methods A total of 101 hospitalized infants with CMV pneumonia were enrolled from January 2011 to December 2012.These patients were divided as the severe pneumonia group (n=48) and the mild pneumonia group (n=53) according to physical sign of lung and complication.Another 55 infants who were hospitalized in the same period with non-infectious diseases were used as the control group.Serum levels of SP-D and MBL were detected by enzyme-linked immunosorbent assay.Blood gas analyzer was used to measure arterial partial pressure of oxygen (PaO2) of the blood in severe patients. Results The mean serum SP-D levels in the severe pneumonia group [(150.08±52.59)ng/ml] and the mild pneumonia group [(109.67±31.39)ng/ml] were significantly higher than those in control group [(41.33±16.42)ng/ml] (P 0.05). In severe patients, serum SP-D levels were negatively correlated with PaO2 (r=-0.565, P<0.01). Conclusion Serum SP-D is associated with the severity of CMV pneumonia, but MBL shows no relation.The serum SP-D levels has an important clinical significance in judgment the sererity of infants with CMV pneumonia. Key words: Surfactant protein D; Mannose-binding lectin; Arterial partial pressure of oxygen; Cytomegalovirus pneumonia; Infant