Abstract
Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur.
 Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance.
 Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant.
 Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.
Highlights
Pregnancy is commonly viewed as cooperative interaction between mother and fetus
All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study
In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%
Summary
Pregnancy is commonly viewed as cooperative interaction between mother and fetus. Since, a combination of maternal and paternal genes forms fetal genotype, a genetic conflict induced by paternally derived factors may exist between mother and fetus during placentation and expression of genes in the fetus dictated by the embryo’s development needs. Continuous struggle and exchange of signals take place between them to maintain equilibrium. Any aberration in this equilibrium could result in events like pre-eclampsia (PE). It has been recognized that edema is consistent part of normal pregnancy, so it has little or no value as diagnostic sign of preeclampsia. A rising serum uric acid level has been recognized as an early feature of preeclampsia and its measurement greatly increases the accuracy of diagnosis. [6, 7] This study was aimed to find out the difference in level of serum uric acid in preeclamptic and healthy pregnant women in third trimester of pregnancy attending obstetrics and gynecology outpatient department of Bahawal Victoria Hospital, Bahawalpur
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