Level of Retinol Deposit and Cervical Cancer

Abstract

Objective: To analyze level of retinol deposit sufficiency in the
 natural history of cervical cancer.
 
 Methods: Serum retinol level was measured by ELISA from
 peripheral blood of subjects with normal cervix, cleared and
 persistent high risk human papilloma virus (HR-HPV) subclinical
 infection, and cervical cancer who fulfilled the inclusion and
 exclusion criteria. The study was held in Dr. Cipto Mangunkusumo
 and Fatmawati Hospital, Jakarta, within 2 years (August 2013-
 2015). Blood was taken twice, consisting of post-8-hour fasting
 blood and 2 hours after 6000 IU retinyl palmitate oral
 administration.
 
 Results: Of 47 total samples, sufficient level of retinol deposit in
 normal cervix, cleared and persistent HR-HPV subclinical infection,
 and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89),
 33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically,
 there was no significant difference from sufficiency level of retinol
 deposit between normal cervix and clearance HR-HPV subclinical
 infection (p=0.628), normal cervix and persistent HR-HPV
 subclinical infection (p=0.078), normal cervix and cervical cancer
 (p=0.433), cervical cancer and clearance HR-HPV subclinical
 infection (p=1.000), cervical cancer and persistent HR-HPV
 subclinical infection (p=0.430), persistent and clearance HR-HPV
 subclinical infection group (p=0.740).
 
 Conclusion: This study proves that normal cervix group has the
 highest level of retinol deposit sufficiency; however, it cannot
 be stated that cervical cancer group has less sufficiency level.
 Persistent HR-HPV subclinical infection group has the lowest
 level of retinol deposit (OR 11.33). There is no association
 between sufficient level of retinol deposit and clearance of
 HR-HPV.
 
 [Indones J Obstet Gynecol 2017; 5-1: 46-54]
 
 Keywords: cervical cancer, HR-HPV clearance, retinol deposit