Abstract
By the method of atomic emission spectrometry with inductively coupled plasma, the content of macro and microelements in the blood plasma of 35 practically healthy people living in the Northern region of Azerbaijan and in the Nizhny Novgorod region of the Russian Federation was studied as well as of 23 patients with pulmonary tuberculosis with different phases of the disease. The elemental homeostasis of the blood plasma did not significantly differ depending on the region of residence, except for the potassium level (by 1.3 times greater for Russians) and strontium (by 10 times higher among the inhabitants of the Northern region of Azerbaijan). In patients with focal pulmonary tuberculosis, there were no significant differences in the content of elements in the blood plasma. With pulmonary tuberculosis, accompanied by decomposition processes, the content of calcium, copper, zinc and iron in blood plasma significantly increases in comparison with healthy people. Analysis of the level of these macro- and microelements can be used to determine the transition of the early form of pulmonary tuberculosis to infiltrative and/or cavernous forms, in which the patient becomes epidemiologically dangerous to others.
Highlights
Radiation imaging techniques, bacterioscopy, cultural and genetic differential methods are used to diagnose pulmonary tuberculosis [1], but often all of the above does not allow us to identify this pathology in the early stages
With pulmonary tuberculosis, accompanied by decomposition processes, the content of calcium, copper, zinc and iron in blood plasma significantly increases in comparison with healthy people
Analysis of the level of these macro- and microelements can be used to determine the transition of the early form of pulmonary tuberculosis to infiltrative and/or cavernous forms, in which the patient becomes epidemiologically dangerous to others
Summary
Bacterioscopy, cultural and genetic differential methods are used to diagnose pulmonary tuberculosis [1], but often all of the above does not allow us to identify this pathology in the early stages. An important clinical significance in the treatment of pulmonary tuberculosis is the evaluation of the effectiveness of the therapy. It is important to keep track of the transition of the early form of pulmonary tuberculosis to infiltrative and/or cavernous forms of pulmonary tuberculosis, in which the patient becomes potentially epidemiologically dangerous to others, effectively becoming an active tuberculosis focus. It is known that the level of micro- and macronutrients in blood plasma varies significantly with various diseases [2]. The available literature data on the violation of elemental homeostasis of blood plasma in pulmonary tuberculosis are quite contradictory [3] [4]. Since the average values of the content of micro- and macronutrients in practically healthy people living in different regions may differ, it is necessary to rely on the values of the norm for a particular area of residence
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