Abstract
Introduction: His-ventricle (H-V) interval is one of the basic measurements of the electrophysiology study (EPS), reflecting conduction time through the His-Purkinje system. Fibrosis and fatty infiltration take a role in the development of H-V interval prolongation. Recent studies claimed that fibrosis in the conduction system could be triggered by oxidative stress. Gamma-glutamyl transferase (GGT) is a non-specific marker of oxidative stress and can be practically evaluated in the clinic. The study aimed to investigate the association of H-V interval prolongation and GGT level. Methods: The study included 94 consecutive patients (58 women) who underwent clinically indicated EPS with the diagnosis of supraventricular tachycardia. Gamma-glutamyl transferase level was measured with routine laboratory tests before the procedure. Atrial-His, H-V intervals and basal cycle length were measured by performing the standard EPS protocol to patients. Results: Patient’s mean age was 47.9±15.8 years. Participants were analyzed in two groups according to the duration of the H-V interval: ≤ 55 ms (n=66) and >55 ms (n=28). Body-mass index (BMI) (OR 1.153, 95% CI 1.029-1.292, p=0.014) and GGT levels (OR 1.060, 95% CI 1.013-1.108, p=0.012) were independently associated with H-V interval prolongation in multivariate logistic regression analysis. Conclusion: Gamma-glutamyl transferase and BMI are independently associated with H-V interval prolongation. The relationship of GGT with H-V interval, which extensive studies should confirm, can be a practical aid in the follow-up of patients with infra-His conduction defects.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Eskisehir Medical Journal, Eskisehir City Hospital
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
