Abstract
AIM:The study analyzed the level of cytokines playing the significant role in the diagnosis of circulatory system diseases and total cardiovascular risk.MATERIAL AND METHODS:The study involved 1,244 residents of Karaganda region. We had studied baseline participant characteristics, in addition to calculating the total cardiovascular risk and assessment of Fatty Acid Binding Proteins 3 (FABP3), Fatty Acid Binding Proteins 4 (FABP4) and N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) level.RESULTS:The results showed the combination of high cardiovascular risk (CVR) with increased titers of cardiac markers, reflecting common pathogenic mechanisms in its development, among residents of Karaganda region.CONCLUSION:The combination of high CVR with the increased titers of cardiac markers showed common pathogenic mechanisms in its development, and support the diagnostic and prognostic value of these parameters among residents of Karaganda region, and also reflects the possibility to include these cardiac markers in the program of screening survey of population for early prevention of cardiovascular disease and its complications.
Highlights
Introduction formation of the European modelSCORE (Systemic Coronary Risk Evaluation)
The combination of high cardiovascular risk (CVR) with the increased titers of cardiac markers showed common pathogenic mechanisms in its development, and support the diagnostic and prognostic value of these parameters among residents of Karaganda region, and reflects the possibility to include these cardiac markers in the program of screening survey of population for early prevention of cardiovascular disease and its complications
The value of each of the selected cardiac markers studied in detail in the pathogenesis and diagnostics of arterial hypertension, congestive heart failure, atherosclerosis, myocardial infarction and stroke
Summary
Introduction formation of the European modelSCORE (Systemic Coronary Risk Evaluation). Blood cardiac markers found the wide use, reflecting the most of section of Currently, according to the data of many epidemiological studies cardiovascular disease remains the leading cause of death in our country and abroad [1,2,3,4,5,6,7]. Prospective studies with the participation of more than 205 thousand patients were conducted in 12 European countries, pathophysiological process and playing the definite prognostic role, in addition to determining of total cardiovascular risk for early diagnosis of CVD [9,10,11,12,13,14,15]. There is insufficient data on the combination of the levels of FABP3, FABP4 and NT-proBNP with a total risk of cardiovascular disease
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