Abstract
Objectives. Quantitative assessment of the expression and co-expression levels of estrogen receptors of different types (ERα and ERβ) in malignant tissues of large cohort of patients with non-small cell lung cancer (NSCLC). Materials and methods . Measurement of ERα and ERβ expression levels was carried out on 167 malignant tissue samples by immunofluorescence flow cytometric method. Level of the ERα and ERβ expression was calculated as a ratio of specifically fluorescent cells (%) compared to the control (incubated with the secondary antibody only). Results. The expression of ERα and ERβ was detected in all the NSCLC samples investigated. High variability in the level of the marker expression was revealed and it was shown 1,5–2,0-fold higher ERβ expression in the most tumors than that for ERα. The Spearman rank correlation coefficient of 0,364 (p <0,001) and the Pearson correlation coefficient of 0,401 (p <0,001) indicate statistically significant weak positive correlation between the levels of expression of ERβ and ERα. Conclusion . The level of expression of ERβ as a main subtype of ER in NSCLC tissue could prove useful for selecting patients for antiestrogen therapy
Highlights
The expression of ERα and ERβ was detected in all the non-small cell lung cancer (NSCLC) samples investigated
The level of expression of ERβ as a main subtype of ER in NSCLC tissue could prove useful for selecting patients for antiestrogen therapy
В целом по группе превышение медианы уровня экспрессии ЭРβ против ЭРα составило 2,3 раза (43 % против 19 %), а различия между реальными показателями у конкретных больных были еще более значительными
Summary
Цель исследования – количественная оценка уровня экспрессии и коэкспрессии эстрогеновых рецепторов разных типов (ЭРα и ЭРβ) в ткани опухолей большой когорты больных немелкоклеточным раком легкого (НМРЛ). Экспрессия ЭРα и ЭРβ выявлена в 100 % исследованных образцов НМРЛ, при этом отмечена значительная вариабельность показателей и в большинстве случаев – превышение уровня экспрессии ЭРβ в сравнении с ЭРα – в 1,5–2,0 раза и более. В целом по группе медиана показателя для ЭРα составила 19 %, а для ЭРβ – 43 %. Коэффициент ранговой корреляции Спирмена оказался равным 0,364 (р
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