Level of Cytokines at Teenagers against the Background of Lambliasis Invasia

T I Ryabichenko,E P Timofeeva,T G Kosianova,T V Kartseva,A N Trunov,G A Skosyreva

doi:10.4236/oji.2014.42007

Abstract

The cytokines’ levels of pro-inflammatory and anti-inflammatory activity, levels of lactoferrin, of the circulating immune complexes and the level of antibodies to antigens of the native deoxyribonucleic acid (DNA) are investigated. The purpose of investigation was to study the pathogenic features of clinical course of chronic lambliasis invasia at teenagers. The statistically significant hypercitokinemia owing to the pro-inflammatory and anti-inflammatory cytokines with the highest concentration of IL-1β, IL-4, the high level of lactoferrin-protein of acute phase, the occurrence of markers of cellular damage, the high level of immune complexes and the stimulation of humoral link of immune system, the high level of antibodies to the antigen of native DNA, are registered. The obtained data may be used as additional diagnostic criteria of lambliasis invasia at teenagers.

Highlights

The long-period persistence of lamblia in a human body shows an adverse effect on immune system and promotes development allergic and autoimmune reactions [1]-[6]
Object of Research: to estimate the level of cytokines at teenagers suffering from lambliasis
The chronic current of lambliasis was observed at teenagers of the 2nd group (93 percent) and was shown in the form of intestinal, hepatobiliary, astenoneurotic, toxic-allergic, anaemic, rheumatoid and the mixed forms

Summary

Introduction

The long-period persistence of lamblia in a human body shows an adverse effect on immune system and promotes development allergic and autoimmune reactions [1]-[6]. “The molecular mimicry” is widespread among parasites when the molecular structure of the fibers of parasite reproduces the structure of number of immune-regulatory fibers of the owner [3] [5]. Some individuals use the cytokines of the owner as the growth factors [7] [8]. All these “strategies” of counteraction to immune sys-. (2014) Level of Cytokines at Teenagers against the Background of Lambliasis Invasia. Object of Research: to estimate the level of cytokines at teenagers suffering from lambliasis

Materials and Methods

Results of Research

Conclusion