Abstract
Studying tumor and metastasis biology is an important challenge of both biology and medicine, since only an experiment may reveal fine mechanisms of pathogenesis. We analyzed the dynamics of serum hormones in a model of rat liver metastates designed by our group, which excluded toxic carcinogen effects, sharp surgical influence and narcosis. The results showed that liver metastases were associated with the following: 1) hyperthyroidism developing at early stages of metastatic process was replaced by latent hypothyroidism after 5 weeks of the carcinogenesis as a result of autoimmune thyroiditis; 2) the increase of progesterone, LG and prolactin levels after 5 weeks of tumor metastasis in liver after the 2 weeks ’ initial decrease; 3) sexual hormones metabolism activation: after a week - increase offree testosterone level, after 2 weeks -rise of estrone and total testosterone and the decrease of estrogen levels after 5 weeks of carcinogenesis; 4) adrenal gland activation leading to the enhancement of serum stress hormone corticosterone and its antagonist DHEA.
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