Level of biogenic amines in pregnant women with psycho-emotional disorders stipulated by anxiety

Abstract

Object of research – to determine level of biogenic amines in pregnant women with psycho-emotional disorders stipulated by anxiety. Group of examined women and methods of research . 90 Pregnant women were examined in ІІ and ІІІ trimester of pregnancy. The main group includes 58 pregnant women with the medium and high level of state anxiety and 32 pregnant women with anxiety level of 30 points and less that indicates the low level of SA (control group). For estimation of the state anxiety and trait anxiety the scale of Spielberger-Hanin was used. Level of serotonin and melatonin was measured with fluorometric method in blood hemolysate of pregnant women. Results . According to the obtained results of biochemical research of hemolysate of packed red cells of blood of examined women it was stated that increase of state anxiety was accompanied by statistically reliable (p < 0.05) rise of serotonin level and decrease of melatonin level. Thus, special features have direct influence on increase (p < 0.05) of serotonin/melatonin index. Pregnant women of the main group have the index which was 2.5 times higher than the same index in women of the control group. Conclusions . Results of performed research among pregnant women have indicated that increase of state anxiety is accompanied by statistically reliable (p < 0.05) rise of serotonin content in blood and statistically reliable (p < 0.05) decrease of melatonin. Such results have direct influence on increase (p < 0.05) of serotonin/melatonin index in pregnant women with medium and high levels of state anxiety comparing to the certain index in women with the low level of anxiety.