Abstract
The aim of this study was to assess levels of adiponectin (ACRP-30) and leptin in serum and synovial fluid (SF) of overweight females with primary gonarthrosis (GOA) and to look for their correlations with clinical status and the level of biochemical OA biomarkers: matrix metalloproteinase (MMP) 1, MMP-9 and tissue inhibitor of metalloproteinase (TIMP-1). The studied group consisted of 39 overweight females undergoing primary total knee arthroplasty as a result of GOA. The stage of GOA was evaluated according to Knee Society Score (KSS), Ahlbäck and Kellgren–Lawrence (K-L) scores. Peripheral blood and SF were obtained. Levels of selected biomarkers were assessed using ELISA kits. The mean level of ACRP-30 in serum valued were 8393.80 ng/mL and in SF, 774.33 ng/mL, the mean concentration of leptin in serum was 32,040.74 pg/mL and in SF, 27,332.12 pg/mL. Levels of leptin in serum and SF correlated with body mass index (BMI), (p = 0.0005, and p = 0.0002, respectively). Levels of ACRP-30 in serum was correlated with clinical scores (Ahlbäck: p = 0.0214; K-L: p = 0.0146). ACRP-30 in SF correlated with ACRP-30 in serum (p = 0.0003), tended to negatively correlate with MMP-1 in serum (p = 0.0598) and positively correlate with pro-MMP-1 in SF (p = 0.0600). To conclude, this study confirms the correlations between concentrations of both, leptin and ACRP-30, comparing serum and SF. In overweight females, leptin levels increase with BMI and ACRP-30 serum level increase in more advanced GOA stages. Finally, leptin levels were correlated with TIMP-1 serum concentration, one of the biochemical markers of GOA.
Highlights
Osteoarthritis (OA) of the knee is a progressive disorder of the knee joints caused by gradual loss of cartilage and resulting in the development of bony spurs and cysts at the margins of the joints
The studied group consisted of 39 post-menopausal females over 50 years of age with body mass index (BMI) over 25 undergoing primary total knee arthroplasty (TKA) because of knee osteoarthritis at the Department of Orthopaedics and Traumatology in Regional
When the results were adjusted for the remaining clinical variables (Age, BMI, Knee Society Score (KSS), Ahlbӓck score, Kellgren–Lawrence score) we found a moderate, positive correlation between serum ACRP-30 measured in serum and Ahlbӓck score (R = 0.393, p = 0.0214)
Summary
Osteoarthritis (OA) of the knee is a progressive disorder of the knee joints caused by gradual loss of cartilage and resulting in the development of bony spurs and cysts at the margins of the joints. OA is the most common form of arthritis and one of the leading causes of disability worldwide affecting around 250 million people [1,2]. The researches proved that OA is not exclusively a degenerative disease of the cartilage, but rather is a multifactorial entity with many possible causative factors such as trauma, mechanical forces, biochemical reactions, inflammation or metabolic derangements [3]. The increased OA frequency in postmenopausal women led to the hypothesis that female hormonal factors may play a causative role [7]
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