Abstract
Leukotrienes, derived from arachidonic acid by the 5-lipoxygenase pathway, have been implicated in unstable angina and in acute myocardial infarction. The aim of the present study was to investigate if leukotriene production is increased in acute and chronic lower limb ischemia. Leukotriene E4 excretion was increased in both acute (152±38 pg/mg creatinine, mean±SEM, n=11,p<0.001) and chronic (140±45 pg/mg creatinine, n=8,p<0.001) lower limb ischemia about 7-fold compared with healthy volunteers (22±3 pg/mg creatinine, n=17). Leukotriene synthesis seems to be increased because of insufficience of blood flow and microcirculation or acute tissue injury. We propose that increased leukotriene synthesis in lower limb ischemia reflects leukocyte activation.
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