Abstract
The relative rates of cysteinyl-leukotriene metabolism were analyzed in fresh human and mouse serum. Human serum contained higher γ-glutamyl-transpeptidase activity than mouse serum, and a higher percentage of the metabolized leukotriene C 4 was recovered as leukotriene D 4 in the human serum than in the mouse serum. The results suggest that the patterns of metabolism of the cysteinyl-leukotrienes could be an important factor in determining the relative sensitivity of an animal to the development of hypersensitivity reactions.
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More From: Biochemical and Biophysical Research Communications
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