Abstract
Leukotriene D 4 (LTD 4) increased the force of contraction in guinea-pig papillary muscle. A rapid (< 1 min), transient (< 5 min) response to LTD 4 (l μM) reached 19.3 ± 5.4% of isoproterenol maximum. A single exposure to LTD 4 resulted in complete and homologous desensitization which was not influenced by indomethacin. LTD 4 (0.1–3.0 μM) increased total inositol phosphates released from [ 3H]inositol-labeled tissue. ICI 198,615, a selective LT receptor antagonist, blocked both the increase in force of contraction and the increase in inositol phosphates by LTD 4, but had no effect on the inotropic response to isoproterenol. These data support the existence of specific functional LTD 4 receptors in myocardial tissue of guinea-pigs.
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