Leukocyte and lipid-based inflammation indices as predictors of asymptomatic organ damage in treatment-naive and newly diagnosed hypertension patients

Abstract

Aim: Low-grade inflammation is known to facilitate the development of hypertensive organ damage. This study aimed to investigate the relationship between the leukocyte and lipid-based inflammation indices and asymptomatic organ damage (AOD) in treatment-naive and newly diagnosed hypertension patients (TNNDH).Methods: The study included 200 patients with TNNDH who are treating by the Cardiology Clinic and 100 healthy controls. Left venriculer mass index (LVMI) of >95 g/m2 in women and >115 g/m2 in men, and carotis intima media thickness (CIMT) of >0.9 mm or presence of plaque in the carotid artery and microalbuminuria of >30 mg/day were evaluated as AOD indicators. Platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), systemic immune-inflammation index (SII), monocyte to HDL ratio (MHR), and atherogenic index of plasma (AIP) levels were calculated based on the complete blood count.Results: Positive correlations were found between all inflammation indices and AOD indicators. AOD was detected in 66.7% of the TNNDH patients. The mean PLR (143.0±37.9 vs. 138.0±36.2; p