Abstract
The effects of varying total doses of intermittent totalbody x irradiation on the development of tumors of the reticuloendothelial system of A strain mice are reported. Three main groups were distinguished: (l) generalized lymphoid leukemia or lymphosarcoma, (2) myeloid leukemia, and (3) localized reticular neoplasms. The only reticular tumor seen in control mice with any frequency was a generalized lymphoid leukemia without thymic enlargement. Radiation resulted in a marked increase in incidence of lymphoid leukemia with thymic enlargement. Lymphoid leukemia without thymic enlargement was little affected by radiation. A number of mice showed aplastic or hypolastic bone marrows, predominantly those with lymphoid leukemia and significantly more in female mice and animals with nonthymic lymphoid leukemia. It is suggested that depression of lymphocytes and myaloid cells may be an important factor in the pathogenesis of lymphoid leukemia after irradiation. Myaloid leukemia and localized reticular neoplasms were rare in these mice. Their incident appeared to be increased after radiation, consistent with the increase in all types of tumors observed in the irradiated animals. (auth)
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