Abstract

VERTICAL transmission of virogenic leukaemia, that is, the occurrence of leukaemia in the untreated progeny of animals inoculated with a leukaemogenic virus, has been observed with four different viruses of murine origin1–5. The phenomenon is not a uniform one. For example, Moloney's virus is transmitted in some strains of mice with little, if any, change of incidence through successive generations ; in other strains, equally susceptible to inoculated virus, it is not transmitted at all4,6. Gross's virus in one strain passes with undiminished incidence to the first generation, but incidence falls off rapidly in subsequent generations ; in other susceptible strains it is not transmitted7–9.

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