Abstract
Dr. Holm's interesting hypothesis has as its core the action of catecholamines on the pulmonary and bronchial vasculature. Our perusal of the reference cited in support of the assertion that norepinephrine causes pulmonary artery vasoconstriction and bronchial artery vasodilation failed to find the expected evidence. In fetal lambs, the response to both methoxamine1 (an α-receptor stimulant) and isoprenaline2 (aβ-receptor stimulant) is pulmonary vasodilation. We are unaware of studies of fetal bronchial arterial responses to catecholamines.
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