Letter to the Editors regarding 'A Meta-Regression of Trial Features Predicting the Effects of Alcohol Use Disorder Pharmacotherapies on Drinking Outcomes in Randomized Clinical Trials: A Secondary Data Analysis'.

Abstract

Short Summary: Grodin et al. conducted a meta-regression analysis of studies testing the effect of pretrial abstinence and diagnosis of alcohol use disorder as treatment effect predictors of pharmacotherapies for alcohol use disorder. The lack of contrast in these predictors and the suboptimal statistical method that was used may explain the negative findings.