Abstract
To the Editor: The −786C allele in the promoter, but not the Asp298 (894T) variant in exon 7, of the endothelial nitric oxide synthase (NOS3) gene has been recently associated with a blunted increase in blood flow average peak velocity induced by acetylcholine in coronary or mammary artery after a 4-week exercise training program.1 By providing a potential explanation for the remarkable individual heterogeneity of responses achieved with exercise in coronary artery disease (CAD) patients, these results extend previous landmark findings from this group.2 The authors carefully excluded patients with arterial hypertension, insulin-dependent diabetes mellitus, smoking, and hypercholesterolemia, eg, conditions that notoriously induce endothelial dysfunction. However, …
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