Abstract
Hofacer et al. [ [1] Hofacer R. Jack Magrisso I. Jandacek R. Rider T. Tso P. Benoit S.C. et al. Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins Leukot. Essent. Fatty Acids. 2012; 86: 71-77 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar ] investigated the mechanisms mediating the effect of n-3 fatty acids on triglyceride (TG) biosynthesis in rats, demonstrating that n-3 fatty acid deficiency up-regulates liver stearoyl-CoA desaturase (SCD)-1 mRNA expression and activity indices (16:1/16:0 and 18:1/18:0 ratios) and increase plasma TG concentrations in vivo. These results were very interesting to us, because we studied the relationship among docosahexaenoic acid (DHA) content in plasma phospholipids, SCD activity indices and the components of metabolic syndrome in obese children [ [2] Saito E. Okada T. Abe Y. Kuromori Y. Miyashita M. Iwata F. et al. Docosahexaenoic acid content in plasma phospholipids and desaturase indices in obese children. J. Atheroscler. Thromb. 2011; 18: 345-350 Crossref PubMed Scopus (30) Google Scholar ].
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