Abstract

This letter discusses the recent study on the effectiveness and safety of Pyrotinib-based therapy in treating HER2-positive breast cancer patients with brain metastases. The study's findings show significant improvements in progression-free survival (PFS) and objective response rate (ORR) when combining Pyrotinib with radiation therapy. It emphasizes the need for further research into multimodal strategies and personalized treatment approaches, including the integration of advanced imaging techniques and artificial intelligence in therapy customization. The letter also highlights the potential for Pyrotinib-based treatments to improve outcomes for patients with historically poor prognoses.

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