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Abstract
The article of Haap et al. in the Experimental and Clinical Endocrinology and Diabetes 117: 289–293 (2009) has drawn my attention. In their interesting work, the authors describe an ACTH producing microadenoma of the pituitary in coincidence with nodular ACTH cell hyperplasias of the anterior lobe, emphasizing that this combination has not been published before. Motivated from this observation, I reviewed the known older literature on this topic. Back in the 1970's I worked on ACTH cell hyperplasias in combination with ACTH cell adenomas, focusing on surgical specimens of patients with Cushing's disease [5] [6] [7] which had been operated with the– at that time just invented–endoscopic transnasal transsphenoidal surgery [2].
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