Abstract
We first reported the association of Myelin oligodendrocyte glycoprotein (MOG) antibodies with COVID-19 vaccines. 29 (17 female; mean age of 38 years) cases of CNS demyelination in patients who received a SARS-CoV-2 vaccine, either first or second dose, within the past 42 days. Twenty-seven occurred in temporal association with ChAdOx1-S vaccine; two in association with BBV152 vaccine. MOG antibodies were positive in 10 (34.5%) patients. One patient with ADEM and tumefactive demyelinating lesions did not respond to immunotherapy and died after a prolonged intensive care unit stay and sepsis. As compared to the control group; the postvaccinial cases were found to have a significantly higher mean age, presence of encephalopathy (p value= 0.0007), CSF pleocytosis (p value=0.0094) and raised CSF protein (p value=0.0062).
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