Letter re: Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

Abstract

The article by Thomas et al.1 validated 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of autopsy-proven dementia with Lewy bodies (DLB). The authors depicted 3 patients with DLB who met pathologic criteria for Lewy body disease but had normal 123I-FP-CIT imaging.1 Although further description concerning severity of parkinsonism remains unclear, these patients may not have severe parkinsonism. Thus, the patients' dopaminergic neuroimaging may not be included in scans without evidence of dopaminergic deficit.