Abstract
To Editor.— An editorial by Samuel Vaisrub (226:1565, 1973) under title Nature's Experiment in Unnatural Aging, discussed possibility of learning from one of nature's mistakes how to retard aging process. He pointed out that progeria, a disease inherited as an autosomal recessive trait, is characterized by precocious senility, and that the afflicted child with his wizened face, dwarfed stature, and general appearance of senility usually dies of coronary heart disease during first or second decade of life. Further evidence of senility has been established by finding deposits of lipofuscin, age in various cells of body, and by incidence of focal fibrosis of myocardium. This pigment, according to Tappel1and other investigators, results from destructive autooxidation (lipid peroxidation) of lipid portion of biological membranes of cells and intracellular organelles. It is believed to represent an important factor
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