Abstract
The results of this experiment allow no valid conclusions regarding the NSD formula. The technique described would appear to provide one quantitative test of the NSD formula if two changes could be made: firstly, interaction of adjacent fields and other artifacts must be eliminated, possibly by using more animals, widely separating fields and using fewer fields per animal; secondly, a new experiment should provide adequate data and measure effects of three dose-options at two levels of “unconventional” fractionation such as 6f./18d. and 12f./26d. in addition to the conventional 3Of./39d. Admitting some bias, we suggest that clinical evaluations be not dismissed too lightly. Our experience with three times weekly fractionation dates back to the 1950's, including all anatomical regions. We are in the process of analysing for publication five years follow-up data of 400 breast cancer patients and 130 prostate cancer patients. Delayed radiation effects fit the NSD formula very well, and excessive late fibrosis does not occur if one avoids the mistake of treating opposed or converging fields alternately.
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