Abstract
A review of the studies on estrogens and endometrial carcinoma attempts to evaluate the large body of facts with an effort to avoid such biases as unintentional histological or hospital selectiveness. En ough evidence has accumulated to suggest that any correlation of estroge n endometrial carcinoma delayed menopause myomas squamous metaplasia of the cervix and cirrhosis are without support. Animal experiments have also yielded little convincing evidence that estrogens cause endometrial carcinoma. Approaches that associate endometrial carcinoma with bleeding at the climacteric and ovarian stromal hyperplasia are still in need of further investigation. Investigations relating persistent proliferative endometriums with endometrial carcinoma suffer from a lack of standard diagnostic criteria. A relationship between feminizing tumors and endometrial carcinoma suggests the incidence to be more than chance. The unique finding in this instance is that only tumors of primary or secondary sex structures coexist with feminizing tumors and corpus cancer.
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