Abstract
To the Editor: For daily clinical practice, it is important to know which lipid-lowering strategy for reaching recommended low-density lipoprotein cholesterol treatment goals is most effective in lowering cardiovascular risk: high-dose statin or low-dose statin in combination with inhibiting intestinal cholesterol uptake. Both strategies lead to a similar 40% to 50% low-density lipoprotein cholesterol reduction. To date, there are no prospective cohort studies with hard clinical end points addressing this issue. In their study, Liu et al1 show that low-risk patients randomized to simvastatin 40 mg had higher flow-mediated dilation (FMD) …
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