Abstract
To the Editor: We read with great interest the recent article by Knottnerus et al1 dealing with the relationship between endothelial activation and lacunar stroke subtypes. The results of their study demonstrated that tissue plasmonogen activator activity, a circulating blood marker of endothelial function, was increased in patients with white matter lesions (WML); WML is a subtpe of lacunar stroke caused by a diffuse small vessel disease. In addition, it was demonstrated that plasmonogen activator inhibitor type 1 antigen levels were lowest in patients with WML. The authors propose that differences in the activity of components of the fibrinolytic system might contribute to WML development in lacunar stroke. Numerous studies have focused on …
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