Letter by Siracusano and Girasole Regarding Article, “Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor γ Coactivator-I Signaling”

Abstract

To the Editor: We read with great interest the article by Schilling et al1 about the role played by the suppression of peroxisome proliferator-activated receptor γ coactivator-1 by the activation of toll-like receptor 4 in septic myocardial dysfunction. The authors stress that the lipopolysaccharide-induced sequential activation of proinflammatory interleukins, toll-like receptor 4, and nuclear factor κB may be the root of the metabolic …