Letter by Santangeli et al Regarding Article, “High-Density Substrate Mapping in Brugada Syndrome: Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis”

Abstract

To the Editor: In their article on high-density substrate mapping in Brugada syndrome, Lambiase and colleagues reported striking endocardial conduction delays in such patients predominantly in the anterolateral right ventricular outflow tract.1 Complex and interesting electrophysiological data are presented, giving new insights into Brugada syndrome features. However, we feel that some methodological flaws in patient characterization, mapping procedure, and data interpretation give different perspectives to their conclusions. It is clear that concealed myocardial diseases, such as arrhythmogenic …