Letter by Ridker and Everett Regarding Article, “The Inflammatory Hypothesis: Any Progress in Risk Stratification and Therapeutic Targets?”

Abstract

To the Editor: We read with interest the recent editorial by Blankenberg and Yusuf1 discussing C-reactive protein (CRP) and atherothrombosis. Whereas Blankenberg and Yusuf write that data from Bos et al2 add “valuable knowledge to the current discussion because no previous studies have examined the impact of CRP on stroke as a unique end point,” we are aware of at least 9 previous publications on this topic. These include data from the Physicians Health Study; the Leiden 85-Plus Study; the National Health and Nutrition Examination Survey (NHANES); the Framingham Heart Study; the Cardiovascular Health Study; the Health, Aging and Body Study; the Honolulu Heart Program; the Atherosclerosis Risk in Communities …