Abstract
To the Editor: With interest we read the article by Kufner et al1 in which they investigated whether smoking is independently associated with recanalization and better functional outcome in patients treated with tissue-type plasminogen activator. They concluded that smokers had a better response to tissue-type plasminogen activator than nonsmokers. In the past decade, several studies have been published regarding this smoking–thrombolysis paradox.2–7 These studies reveal conflicting results. We performed a meta-analysis of studies that investigated this smoking–thrombolysis paradox. We searched PubMed with combinations of the following terms: outcome, smoking, stroke, and thrombolysis. We selected only studies from which we could extract data for an unadjusted meta-analysis. On …
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