Abstract
In a dose-response meta-analysis of prospective studies, Mostofsky et al1 report a J-shaped relationship between coffee consumption and risk of heart failure. However, as the authors themselves point out, this study missed important information about potential modifiers of this association. Mostofsky et al1 put emphasis only on caffeine when discussing the relationship of coffee with heart failure. However, coffee is a blend of a vast number of bioactive chemicals, with different effects on the cardiovascular system. Among these, the polyphenols chlorogenic acid and dihydrocaffeic acid seem to act as protective antioxidants and have other beneficial actions on the cardiovascular system.2 The overall …
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