Abstract
In a recent issue of Circulation , the article “Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice” by Simsekyilmaz et al1 showed us the plaque progression in atherosclerosis-prone mice driven by extracellular RNA (eRNA) in an inflammation-dependent manner. The study is important because the authors, first of all, demonstrated the role of eRNA/RNase system in the pathogenesis of atherosclerosis, which would have potential clinical application. However, we have some concerns about the strength of their conclusion that toll-like receptor (TLR) signaling was not involved in the eRNA-induced inflammatory responses in macrophages. Based on the findings that there was no alteration of Stat1 expression …
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